TY - JOUR AU - cura della Redazione, A T1 - L’uso cronico di oppioidi aumenta la sensibilità al dolore? PY - 2017 Y1 - 2017-04-01 DO - 10.1702/2721.27756 JO - Assistenza Infermieristica e Ricerca JA - Assist Inferm Ric VL - 36 IS - 2 SP - 101 EP - 103 PB - Il Pensiero Scientifico Editore SN - 2038-1778 Y2 - 2024/03/29 UR - http://dx.doi.org/10.1702/2721.27756 N2 - Summary. Do opioids make chronic users more sensitive to pain? At high doses opioids seem to amplify pain by changing signaling in the central nervous system, making the body more sensitive to pain. This phenomenon is already known but difficult to diagnose, thus its prevalence is unknown. It is assumed that it could play a role in the epidemics of opioids abuse. The mechanisms of opioids induced hyperalgesia and the most recent research to describe and revers it are described. ER -